Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis

Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis

Previous studies have demonstrated that gestational diabetes mellitus (GDM) and Type 2 diabetes mellitus (T2D) share common genetic polymorphisms. We conducted meta-analysis and subgroup analysis of all available variants and determined the effects of confounding and experimental components on the genetic association of GDM. Any case-controlled or cohort studies with genotype distribution compa...

Prevalence of Gestational diabetes mellitus in Iran: A Systematic Review and Meta-analysis

Serum homocysteine level and gestational diabetes mellitus: A meta‐analysis

AIMS/INTRODUCTION Homocysteine levels during pregnancy in women with gestational diabetes mellitus (GDM) have been studied; however, it remains unclear whether hyperhomocysteinemia is a useful predictor of insulin resistance. The present study aimed to evaluate the relationship between homocysteine level and GDM. MATERIALS AND METHODS PubMed, Elsevier, Web of Science and CNKI were searched fo...

Genetic variants in PTPRD and risk of gestational diabetes mellitus

Genome-wide association studies (GWASs) showed that two single nucleotide polymorphisms (SNPs) (rs17584499 and rs649891) in the protein tyrosine phosphatase receptor type D (PTPRD) were associated with type 2 diabetes (T2D). We sought to determine the influence of the PTPRD variants on the gestational diabetes mellitus (GDM) risk. In this research, two SNPs in PTPRD reported in T2D GWASs and si...

Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus

BACKGROUND A number of case-control studies were conducted to investigate the association of common type 2 diabetes (T2D) risk gene polymorphisms with gestational diabetes mellitus (GDM). However, these studies have yielded contradictory results. We therefore performed a meta-analysis to derive a more precise estimation of the association between these polymorphisms and GDM, hence achieve a bet...